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Under conditions of hepatic copper excess, the high-affinity transporter CTR1 undergoes endocytosis and degradation to reduce further uptake, while ATP7B expression is upregulated to promote copper excretion via bile (29,51)

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A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

At higher maintenance doses like 2.4mg per week, a 10mg vial lasts roughly four weeks, which aligns neatly with the 28-day stability window

So, Im thinking, well, when you forget stuff, a name or something, Oh man, that must be my amyloid and tau in my brain, whatever. So, this breakthrough, the biggest breakthrough in neuroscience in decades, is this p-tau217